                         SEQUENCE LISTING

<110>  wyeth
 
<120>  METHODS OF TREATING BONE DISORDERS WITH MODULATORS OF AXL

<130>  AM102169

<150>  60/958270
<151>  2007-07-02

<150>  60/958316
<151>  2007-07-03

<160>  43    

<170>  PatentIn version 3.3

<210>  1
<211>  5014
<212>  DNA
<213>  Homo sapiens

<400>  1
gagtggagtt ctggaggaat gtttaccaga cacagagccc agagggacag cgcccagagc     60

ccagatagag agacacggcc tcactggctc agcaccaggg tccccttccc cctcctcagc    120

tccctccctg gcccctttaa gaaagagctg atcctctcct ctcttgagtt aacccctgat    180

tgtccaggtg gcccctggct ctggcctggt gggcggaggc aaagggggag ccaggggcgg    240

agaaagggtt gcccaagtct gggagtgagg gaaggaggca ggggtgctga gaaggcggct    300

gctgggcaga gccggtggca agggcctccc ctgccgctgt gccaggcagg cagtgccaaa    360

tccggggagc ctggagctgg ggggagggcc ggggacagcc cggccctgcc ccctcccccg    420

ctgggagccc agcaacttct gaggaaagtt tggcacccat ggcgtggcgg tgccccagga    480

tgggcagggt cccgctggcc tggtgcttgg cgctgtgcgg ctgggcgtgc atggccccca    540

ggggcacgca ggctgaagaa agtcccttcg tgggcaaccc agggaatatc acaggtgccc    600

ggggactcac gggcaccctt cggtgtcagc tccaggttca gggagagccc cccgaggtac    660

attggcttcg ggatggacag atcctggagc tcgcggacag cacccagacc caggtgcccc    720

tgggtgagga tgaacaggat gactggatag tggtcagcca gctcagaatc acctccctgc    780

agctttccga cacgggacag taccagtgtt tggtgtttct gggacatcag accttcgtgt    840

cccagcctgg ctatgttggg ctggagggct tgccttactt cctggaggag cccgaagaca    900

ggactgtggc cgccaacacc cccttcaacc tgagctgcca agctcaggga cccccagagc    960

ccgtggacct actctggctc caggatgctg tccccctggc cacggctcca ggtcacggcc   1020

cccagcgcag cctgcatgtt ccagggctga acaagacatc ctctttctcc tgcgaagccc   1080

ataacgccaa gggggtcacc acatcccgca cagccaccat cacagtgctc ccccagcagc   1140

cccgtaacct ccacctggtc tcccgccaac ccacggagct ggaggtggct tggactccag   1200

gcctgagcgg catctacccc ctgacccact gcaccctgca ggctgtgctg tcagacgatg   1260

ggatgggcat ccaggcggga gaaccagacc ccccagagga gcccctcacc tcgcaagcat   1320

ccgtgccccc ccatcagctt cggctaggca gcctccatcc tcacacccct tatcacatcc   1380

gcgtggcatg caccagcagc cagggcccct catcctggac ccactggctt cctgtggaga   1440

cgccggaggg agtgcccctg ggcccccctg agaacattag tgctacgcgg aatgggagcc   1500

aggccttcgt gcattggcaa gagccccggg cgcccctgca gggtaccctg ttagggtacc   1560

ggctggcgta tcaaggccag gacaccccag aggtgctaat ggacataggg ctaaggcaag   1620

aggtgaccct ggagctgcag ggggacgggt ctgtgtccaa tctgacagtg tgtgtggcag   1680

cctacactgc tgctggggat ggaccctgga gcctcccagt acccctggag gcctggcgcc   1740

cagggcaagc acagccagtc caccagctgg tgaaggaacc ttcaactcct gccttctcgt   1800

ggccctggtg gtatgtactg ctaggagcag tcgtggccgc tgcctgtgtc ctcatcttgg   1860

ctctcttcct tgtccaccgg cgaaagaagg agacccgtta tggagaagtg tttgaaccaa   1920

cagtggaaag aggtgaactg gtagtcaggt accgcgtgcg caagtcctac agtcgtcgga   1980

ccactgaagc taccttgaac agcctgggca tcagtgaaga gctgaaggag aagctgcggg   2040

atgtgatggt ggaccggcac aaggtggccc tggggaagac tctgggagag ggagagtttg   2100

gagctgtgat ggaaggccag ctcaaccagg acgactccat cctcaaggtg gctgtgaaga   2160

cgatgaagat tgccatctgc acgaggtcag agctggagga tttcctgagt gaagcggtct   2220

gcatgaagga atttgaccat cccaacgtca tgaggctcat cggtgtctgt ttccagggtt   2280

ctgaacgaga gagcttccca gcacctgtgg tcatcttacc tttcatgaaa catggagacc   2340

tacacagctt cctcctctat tcccggctcg gggaccagcc agtgtacctg cccactcaga   2400

tgctagtgaa gttcatggca gacatcgcca gtggcatgga gtatctgagt accaagagat   2460

tcatacaccg ggacctggcg gccaggaact gcatgctgaa tgagaacatg tccgtgtgtg   2520

tggcggactt cgggctctcc aagaagatct acaatgggga ctactaccgc cagggacgta   2580

tcgccaagat gccagtcaag tggattgcca ttgagagtct agctgaccgt gtctacacca   2640

gcaagagcga tgtgtggtcc ttcggggtga caatgtggga gattgccaca agaggccaaa   2700

ccccatatcc gggcgtggag aacagcgaga tttatgacta tctgcgccag ggaaatcgcc   2760

tgaagcagcc tgcggactgt ctggatggac tgtatgcctt gatgtcgcgg tgctgggagc   2820

taaatcccca ggaccggcca agttttacag agctgcggga agatttggag aacacactga   2880

aggccttgcc tcctgcccag gagcctgacg aaatcctcta tgtcaacatg gatgagggtg   2940

gaggttatcc tgaaccccct ggagctgcag gaggagctga ccccccaacc cagccagacc   3000

ctaaggattc ctgtagctgc ctcactgcgg ctgaggtcca tcctgctgga cgctatgtcc   3060

tctgcccttc cacaacccct agccccgctc agcctgctga taggggctcc ccagcagccc   3120

cagggcagga ggatggtgcc tgagacaacc ctccacctgg tactccctct caggatccaa   3180

gctaagcact gccactgggg aaaactccac cttcccactt tcccacccca cgccttatcc   3240

ccacttgcag ccctgtcttc ctacctatcc cacctccatc ccagacaggt ccctcccctt   3300

ctctgtgcag tagcatcacc ttgaaagcag tagcatcacc atctgtaaaa ggaaggggtt   3360

ggattgcaat atctgaagcc ctcccaggtg ttaacattcc aagactctag agtccaaggt   3420

ttaaagagtc tagattcaaa ggttctaggt ttcaaagatg ctgtgagtct ttggttctaa   3480

ggacctgaaa ttccaaagtc tctaattcta ttaaagtgct aaggttctaa ggcctacttt   3540

tttttttttt tttttttttt tttttttttt tgcgatagag tctcactgtg tcacccaggc   3600

tggagtgcag tggtgcaatc tcgcctcact gcaaccttca cctaccgagt tcaagtgatt   3660

ttcctgcctt ggcctcccaa gtagctggga ttacaggtgt gtgccaccac acccggctaa   3720

tttttatatt tttagtagag acagggtttc accatgttgg ccaggctggt ctaaaactcc   3780

tgacctcaag tgatctgccc acctcagcct cccaaagtgc tgagattaca ggcatgagcc   3840

actgcactca accttaagac ctactgttct aaagctctga cattatgtgg ttttagattt   3900

tctggttcta acatttttga taaagcctca aggttttagg ttctaaagtt ctaagattct   3960

gattttagga gctaaggctc tatgagtcta gatgtttatt cttctagagt tcagagtcct   4020

taaaatgtaa gattatagat tctaaagatt ctatagttct agacatggag gttctaaggc   4080

ctaggattct aaaatgtgat gttctaaggc tctgagagtc tagattctct ggctgtaagg   4140

ctctagatca taaggcttca aaatgttatc ttctcaagtt ctaagattct aatgatgatc   4200

aattatagtt tctgaggctt tatgataata gattctcttg tataagatcc tagatcctaa   4260

gggtcgaaag ctctagaatc tgcaattcaa aagttccaag agtctaaaga tggagtttct   4320

aaggtccggt gttctaagat gtgatattct aagacttact ctaagatctt agattctctg   4380

tgtctaagat tctagatcag atgctccaag attctagatg attaaataag attctaacgg   4440

tctgttctgt ttcaaggcac tctagattcc attggtccaa gattccggat cctaagcatc   4500

taagttataa gactctcaca ctcagttgtg actaactaga caccaaagtt ctaataattt   4560

ctaatgttgg acacctttag gttctttgct gcattctgcc tctctaggac catggttaag   4620

agtccaagaa tccacatttc taaaatctta tagttctagg cactgtagtt ctaagactca   4680

aatgttctaa gtttctaaga ttctaaaggt ccacaggtct agactattag gtgcaatttc   4740

aaggttctaa ccctatactg tagtattctt tggggtgccc ctctccttct tagctatcat   4800

tgcttcctcc tccccaactg tgggggtgtg cccccttcaa gcctgtgcaa tgcattaggg   4860

atgcctcctt tcccgcaggg gatggacgat ctcccacctt tcgggccatg ttgcccccgt   4920

gagccaatcc ctcaccttct gagtacagag tgtggactct ggtgcctcca gaggggctca   4980

ggtcacataa aactttgtat atcaacgaaa aaaa                               5014


<210>  2
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  3
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Axl-specific siRNA

<400>  3
ggaaagaggu gaacugguau u                                               21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Axl-specific siRNA

<400>  4
caagaugaau ggaaaguugu u                                               21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Axl-specific siRNA

<400>  5
ggaacugcau gcugaaugau u                                               21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Axl-specific siRNA

<400>  6
ggaagaagga gacucgauau u                                               21


<210>  7
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  control siRNA

<400>  7
gguagcuauu caguuacug                                                  19


<210>  8
<211>  20
<212>  RNA
<213>  Artificial

<220>
<223>  Runx2/Cbfa1-specific siRNA

<400>  8
cgugaauggu cauaauaacu                                                 20


<210>  9
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer used to detect osteocalcin

<400>  9
cggccctgag tctgacaaa                                                  19


<210>  10
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer used to detect osteocalcin

<400>  10
gccggagtct gttcactacc tt                                              22


<210>  11
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer used to detect osteocalcin

<400>  11
ccttcatgtc caagcaggag ggca                                            24


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp 
1               5                   10                  


<210>  13
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly His His His His His His Arg Arg Lys Lys Glu Thr Arg Tyr 
1               5                   10                  15      


Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val Arg 
            20                  25                  30          


Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu 
        35                  40                  45              


Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp Val 
    50                  55                  60                  


Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu Gly 
65                  70                  75                  80  


Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile 
                85                  90                  95      


Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg Ser 
            100                 105                 110         


Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe Asp 
        115                 120                 125             


His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser Glu 
    130                 135                 140                 


Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys His 
145                 150                 155                 160 


Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro 
                165                 170                 175     


Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile Ala 
            180                 185                 190         


Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp Leu 
        195                 200                 205             


Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val Ala 
    210                 215                 220                 


Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln 
225                 230                 235                 240 


Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser Leu 
                245                 250                 255     


Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly Val 
            260                 265                 270         


Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val 
        275                 280                 285             


Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys 
    290                 295                 300                 


Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys 
305                 310                 315                 320 


Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu 
                325                 330                 335     


Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp 
            340                 345                 350         


Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro 
        355                 360                 365             


Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys 
    370                 375                 380                 


Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly Arg 
385                 390                 395                 400 


Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp 
                405                 410                 415     


Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
            420                 425                 


<210>  14
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
1               5                   10                  15      


Cys Trp Glu Leu Asn 
            20      


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly 
1               5                   10                  15      


Arg Ile Ala Lys 
            20  


<210>  16
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys 
1               5                   10              


<210>  17
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly 
1               5                   10          


<210>  18
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  18
cggacatcag accttcgtgt cttcctgtca acacgaaggt ctgatgtcc                 49


<210>  19
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  19
cgcgtatcaa ggccaggaca cttcctgtca tgtcctggcc ttgatacgc                 49


<210>  20
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  20
cgagtgaagc ggtctgcatg cttcctgtca catgcagacc gcttcactc                 49


<210>  21
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  21
cgagtaccaa gagattcata cttcctgtca tatgaatctc ttggtactc                 49


<210>  22
<211>  49
<212>  DNA
<213>  Homo sapiens

<400>  22
cgacgaaatc ctctatgtca cttcctgtca tgacatagag gatttcgtc                 49


<210>  23
<211>  49
<212>  DNA
<213>  Mus musculus

<400>  23
cggcttcgag atggacagat cttcctgtca atctgtccat ctcgaagcc                 49


<210>  24
<211>  49
<212>  DNA
<213>  Mus musculus

<400>  24
cgtaccggct ggcatatcga cttcctgtca tcgatatgcc agccggtac                 49


<210>  25
<211>  49
<212>  DNA
<213>  Mus musculus

<400>  25
cgtgtccgaa agtcctacag cttcctgtca ctgtaggact ttcggacac                 49


<210>  26
<211>  49
<212>  DNA
<213>  Mus musculus

<400>  26
cgaaacacgg agacctacac cttcctgtca gtgtaggtct ccgtgtttc                 49


<210>  27
<211>  49
<212>  DNA
<213>  Mus musculus

<400>  27
cgtcaaggaa atcggctgaa cttcctgtca ttcagccgat ttccttgac                 49


<210>  28
<211>  19
<212>  RNA
<213>  Artificial

<220>
<223>  Budagian et al. siRNA

<400>  28
uaucacaggu gccagagga                                                  19


<210>  29
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Budagian et al. siRNA

<400>  29
aagacauccu cuuucuccug c                                               21


<210>  30
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  Budagian et al. siRNA

<400>  30
aagauuugga gaacacacug a                                               21


<210>  31
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Holland et al shRNA

<400>  31
gacatcctct ttctcctgcg aagcccatga agcttgatgg gcttcgcagg agaaagagga     60

tgtc                                                                  64


<210>  32
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Holland et al. shRNA

<400>  32
gatttggaga acacactgaa ggccttgcga agcttggcaa ggccttcagt gtgttctcca     60

aatc                                                                  64


<210>  33
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  33

Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro Pro Glu Val His 
1               5                   10                  15      


Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr 
            20                  25                  30          


Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser 
        35                  40                  45              


Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln 
    50                  55                  60                  


Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr 
65                  70                  75                  80  


Val Gly Leu Glu 
                


<210>  34
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala Ala 
1               5                   10                  15      


Asn Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu Pro 
            20                  25                  30          


Val Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala Pro 
        35                  40                  45              


Gly His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys Thr 
    50                  55                  60                  


Ser Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr Ser 
65                  70                  75                  80  


Arg Thr Ala Thr Ile Thr 
                85      


<210>  35
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  35

Ala Gly Ala Gly Gly Gly Thr Asp Glu Gly Ile Tyr Asp Val Pro Leu 
1               5                   10                  15      


Leu 
    


<210>  36
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  36

Ala Gly Ala Gly Gly Pro Gln Asp Ile Tyr Asp Val Pro Pro Val Arg 
1               5                   10                  15      


<210>  37
<211>  429
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
1               5                   10                  15      


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
            20                  25                  30          


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
        35                  40                  45              


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
    50                  55                  60                  


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
65                  70                  75                  80  


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
                85                  90                  95      


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
            100                 105                 110         


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
        115                 120                 125             


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala 
    130                 135                 140                 


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
145                 150                 155                 160 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln 
                165                 170                 175     


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
            180                 185                 190         


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
        195                 200                 205             


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
    210                 215                 220                 


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
225                 230                 235                 240 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
                245                 250                 255     


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
            260                 265                 270         


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
        275                 280                 285             


Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu 
    290                 295                 300                 


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln 
305                 310                 315                 320 


Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
                325                 330                 335     


Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn 
            340                 345                 350         


Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly 
        355                 360                 365             


Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu 
    370                 375                 380                 


Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser 
385                 390                 395                 400 


Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala 
                405                 410                 415     


Pro Gly Gln Glu Asp Gly Ala His His His His His His 
            420                 425                 


<210>  38
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr 
1               5                   10                  15      


Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu 
            20                  25                  30          


Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys 
        35                  40                  45              


Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn 
    50                  55                  60                  


Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala 
65                  70                  75                  80  


Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys 
                85                  90                  95      


Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys 
            100                 105                 110         


Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu 
        115                 120                 125             


Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg 
    130                 135                 140                 


Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe 
145                 150                 155                 160 


Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe 
                165                 170                 175     


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met 
            180                 185                 190         


Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly 
        195                 200                 205             


Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile 
    210                 215                 220                 


Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val 
225                 230                 235                 240 


Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr 
                245                 250                 255     


Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln 
            260                 265                 270         


Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala 
        275                 280                 285             


Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe 
    290                 295                 300                 


Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro 
305                 310                 315                 320 


Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly 
                325                 330                 335     


Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr 
            340                 345                 350         


Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val 
        355                 360                 365             


His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro 
    370                 375                 380                 


Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp 
385                 390                 395                 400 


Gly Ala 
        


<210>  39
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys 
1               5                   10                  15      


Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr 
            20                  25                  30          


Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln 
        35                  40                  45              


Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile 
    50                  55                  60                  


Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met 
65                  70                  75                  80  


Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe 
                85                  90                  95      


Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro 
            100                 105                 110         


Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu 
        115                 120                 125             


Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met 
    130                 135                 140                 


Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile 
145                 150                 155                 160 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser 
                165                 170                 175     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp 
            180                 185                 190         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        195                 200                 205             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    210                 215                 220                 


Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro 
225                 230                 235                 240 


Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly 
                245                 250                 255     


Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu 
            260                 265                 270         


Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Ala 
        275                 280                 285             


Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala 
    290                 295                 300                 


Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly 
305                 310                 315                 320 


Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln 
                325                 330                 335     


Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His 
            340                 345                 350         


Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala 
        355                 360                 365             


Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly 
    370                 375                 380                 


Ala 
385 


<210>  40
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly 
1               5                   10                  15      


Glu Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp 
            20                  25                  30          


Ser Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr 
        35                  40                  45              


Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu 
    50                  55                  60                  


Phe Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly 
65                  70                  75                  80  


Ser Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met 
                85                  90                  95      


Lys His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp 
            100                 105                 110         


Gln Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp 
        115                 120                 125             


Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg 
    130                 135                 140                 


Asp Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys 
145                 150                 155                 160 


Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr 
                165                 170                 175     


Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu 
            180                 185                 190         


Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe 
        195                 200                 205             


Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro 
    210                 215                 220                 


Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg 
225                 230                 235                 240 


Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser 
                245                 250                 255     


Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Ala Glu Leu 
            260                 265                 270         


Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu 
        275                 280                 285             


Pro Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro 
    290                 295                 300                 


Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp 
305                 310                 315                 320 


Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala 
                325                 330                 335     


Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro 
            340                 345                 350         


Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
        355                 360                 365         


<210>  41
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
1               5                   10                  15      


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
            20                  25                  30          


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
        35                  40                  45              


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
    50                  55                  60                  


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
65                  70                  75                  80  


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
                85                  90                  95      


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
            100                 105                 110         


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
        115                 120                 125             


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala 
    130                 135                 140                 


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
145                 150                 155                 160 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln 
                165                 170                 175     


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
            180                 185                 190         


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
        195                 200                 205             


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
    210                 215                 220                 


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
225                 230                 235                 240 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
                245                 250                 255     


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
            260                 265                 270         


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
        275                 280                 285             


Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu 
    290                 295                 300                 


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln 
305                 310                 315                 320 


Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
                325                 330                 335     


Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn 
            340                 345                 350         


Met Asp 
        


<210>  42
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
1               5                   10                  15      


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
            20                  25                  30          


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
        35                  40                  45              


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
    50                  55                  60                  


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
65                  70                  75                  80  


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
                85                  90                  95      


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
            100                 105                 110         


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
        115                 120                 125             


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala 
    130                 135                 140                 


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
145                 150                 155                 160 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln 
                165                 170                 175     


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
            180                 185                 190         


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
        195                 200                 205             


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
    210                 215                 220                 


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
225                 230                 235                 240 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
                245                 250                 255     


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
            260                 265                 270         


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
        275                 280                 285             


Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu 
    290                 295                 300                 


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln 
305                 310                 315                 320 


Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
                325                 330                 335     


Lys 
    


<210>  43
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  43

Met His Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro 
1               5                   10                  15      


Thr Val Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser 
            20                  25                  30          


Tyr Ser Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser 
        35                  40                  45              


Glu Glu Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys 
    50                  55                  60                  


Val Ala Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met 
65                  70                  75                  80  


Glu Gly Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys 
                85                  90                  95      


Thr Met Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu 
            100                 105                 110         


Ser Glu Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg 
        115                 120                 125             


Leu Ile Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala 
    130                 135                 140                 


Pro Val Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe 
145                 150                 155                 160 


Leu Leu Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln 
                165                 170                 175     


Met Leu Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu 
            180                 185                 190         


Ser Thr Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met 
        195                 200                 205             


Leu Asn Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys 
    210                 215                 220                 


Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met 
225                 230                 235                 240 


Pro Val Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr 
                245                 250                 255     


Ser Lys Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala 
            260                 265                 270         


Thr Arg Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr 
        275                 280                 285             


Asp Tyr Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu 
    290                 295                 300                 


Asp Gly Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln 
305                 310                 315                 320 


Asp Arg Pro Ser Phe Ala Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu 
                325                 330                 335     


Lys Ala Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn 
            340                 345                 350         


Met Asp Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly 
        355                 360                 365             


Ala Asp Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu 
    370                 375                 380                 


Thr Ala Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser 
385                 390                 395                 400 


Thr Thr Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala 
                405                 410                 415     


Pro Gly Gln Glu Asp Gly Ala Gly His His His His His His 
            420                 425                 430 


